Advanced Peptide Treatment for Aging Lips

Overnight lip restoration designed to address skin aging at the cellular level.

OS-01 LIP MASK is a next-generation overnight treatment formulated with OneSkin's proprietary OS-01 peptide, a senotherapeutic peptide designed to reduce markers of cellular senescence — one of the key biological drivers of skin aging. Unlike traditional lip balms that focus primarily on surface occlusion, OS-01 LIP MASK is engineered to support healthier lip skin function by targeting aging processes within the cells of this uniquely thin, vulnerable tissue.

What Makes OS-01 Different
Most lip products address dryness or fine lines after they appear — relying on temporary occlusives to plump or smooth. OS-01 LIP MASK works upstream by addressing senescent skin cells in the lip area, which accumulate with age and contribute to thinning, loss of definition, and reduced moisture retention.

Key Benefits

• Targets biological drivers of lip aging
• Stimulates the lips' natural production of collagen, elastin, and hyaluronic acid
• Supports fuller, smoother, more defined lip contour
• Delivers long-lasting hydration without stickiness or shine
• Designed for nightly use during the skin's peak repair window

Key Active Ingredient
OS-01 Peptide™ A patented peptide identified through AI-driven screening for its ability to reduce markers of cellular senescence in human skin cells. In clinical testing on the lip area, the majority of users reported lips that stayed hydrated through the night and showed visibly fewer fine lines and wrinkles over time.

Formulation Highlights

• Dermatologist tested
• Fragrance-free and flavor-free
• Vegan and sustainably sourced
• Suitable for sensitive skin
• Free from parabens, sulfates, phthalates, synthetic fragrance, lanolin, and mineral oil
• Enhanced with microalgae, ceramides and squalane, astaxanthin, and a secondary firming peptide (palmitoyl hexapeptide-12)

Who This Is For

Individuals concerned with thinning, fine lines, or loss of fullness in the lip area
Patients undergoing aesthetic treatments who want to support lip recovery and maintain results between procedures
Those seeking a science-driven, peptide-based alternative to fillers or traditional balms

How to Use
Using the included applicator, apply a generous layer to clean, dry lips before bed and leave on overnight. Can also be used throughout the day as needed for added hydration. Pairs well with OS-01 LIP SPF for daytime UV protection.